Neuroblastoma with high ASPM reveals pronounced heterogeneity and poor prognosis.

ABSTRACT:

Objective

We explored the preliminary value of abnormal spindle-like microcephaly- associated (ASPM) protein in aiding precise risk sub-stratification, prediction of metabolic heterogeneity, and prognosis of neuroblastoma (NB).

Methods

This retrospective study enrolled newly diagnosed patients with NB who underwent positron emission tomography/computed tomography (PET/CT) before therapy, and tumor tissue was collected after surgery. Regression analysis was used to evaluate ASPM expression and risk stratification in patients with NB. The expression levels of ASPM, clinical information, and PET/CT text features were analyzed using univariate and multivariate survival analyses. Finally, a correlation analysis was used to explore the relationship between ASPM and tumor metabolic

SUBMITTER: Li C 

PROVIDER: S-EPMC11406734 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature