Blood-based HYAL2 methylation as a potential marker for the preclinical detection of coronary heart disease and stroke.

ABSTRACT:

Background

Coronary heart disease (CHD) and stroke have become the leading cause of premature mortality and morbidity worldwide. Therefore, sensitive and accurate biomarkers for early detection of CHD and stroke are urgently needed for effective prevention and treatment. We aim to investigate the association between blood-based HYAL2 methylation and the risk of CHD and stroke in Chinese population.

Methods

In a prospective nested case-control study comprising 171 CHD cases, 139 stroke cases, who developed the diseases after recruitment and 356 controls who remained healthy during the 2.5 years of follow-up time, the methylation level of HYAL2 in the peripheral blood was quantified using mass spectrometry, and the association was calculated by logistic regression adjusted for

SUBMITTER: Bi L 

PROVIDER: S-EPMC11406760 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature