A novel pulmonary fibrosis NOD/SCID murine model with natural aging.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) is an age-related disease severely affecting life quality with its prevalence rising as the population ages, yet there is still no effective treatment available. Cell therapy has emerged as a promising option for IPF, however, the absence of mature and stable animal models for IPF immunodeficiency hampers preclinical evaluations of human cell therapies, primarily due to rapid immune clearance of administered cells. This study aims to establish a reliable pulmonary fibrosis (PF) model in immunodeficient mice that supports autologous cell therapy and to investigate underlying mechanism.

Methods

We utilized thirty 5-week-old male NOD/SCID mice, categorizing them into three age groups: 12weeks, 32 weeks and 43 weeks, with 6 mice eut

SUBMITTER: Ma Z 

PROVIDER: S-EPMC11406766 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature