The direct inhibitory effects of Lactobacillus acidophilus, a commensal urinary bacterium, on calcium oxalate stone development.

ABSTRACT:

Background

Lactobacillus acidophilus is a commensal urinary bacterium found more abundantly in healthy individuals than in stone patients. Hence, it has been proposed to play an inhibitory role in kidney stone disease (KSD) but with unclear mechanisms. We therefore investigated the direct effects of L. acidophilus on calcium oxalate (CaOx) stone development compared with Escherichia coli, which is known to promote CaOx stone formation.

Results

L. acidophilus at 1 × 10³ CFU/ml  significantly reduced the abundance of newly formed crystals, enlargement and aggregation of seeded crystals, and crystal adhesion on renal cell membranes. By contrast, E. coli at 1 × 10³ CFU/ml significantly enhanced crystal growth and aggregation but did not affect crystallizati

SUBMITTER: Noonin C 

PROVIDER: S-EPMC11406782 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature