Histological differences related to autophagy in the minor salivary gland between primary and secondary types of Sjogren's syndrome.

ABSTRACT: Some forms of Sjögren's syndrome (SS) follow a clinical course accompanied by systemic symptoms caused by lymphocyte infiltration and proliferation in the liver, kidneys, and other organs. To better understand the clinical outcomes of SS, here we used minor salivary gland tissues from patients and examine their molecular, biological, and pathological characteristics. A retrospective study was performed, combining clinical data and formalin-fixed paraffin-embedded (FFPE) samples from female patients over 60 years of age who underwent biopsies at Okayama University Hospital. We employed direct digital RNA counting with nCounter^® and multiplex immunofluorescence analysis with a PhenoCycler™ on the labial gland biopsies. We compared FFPE samples from SS patients who presented with o

SUBMITTER: Ono-Minagi H 

PROVIDER: S-EPMC11406829 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature