Whole-genome sequencing of major malaria vectors reveals the evolution of new insecticide resistance variants in a longitudinal study in Burkina Faso.

ABSTRACT:

Background

Intensive deployment of insecticide based malaria vector control tools resulted in the rapid evolution of phenotypes resistant to these chemicals. Understanding this process at the genomic level is important for the deployment of successful vector control interventions. Therefore, longitudinal sampling followed by whole genome sequencing (WGS) is necessary to understand how these evolutionary processes evolve over time. This study investigated the change in genetic structure and the evolution of the insecticide resistance variants in natural populations of Anopheles gambiae over time and space from 2012 to 2017 in Burkina Faso.

Methods

New genomic data have been generated from An. gambiae mosquitoes collected from three villages in the western part of Burkina Faso

SUBMITTER: Kientega M 

PROVIDER: S-EPMC11406867 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature