Integration of texture analysis based on DCE-MRI K^trans map and metabolomics of early bone marrow microvascular changes in alloxan-induced diabetic rabbits.

ABSTRACT:

Objective

To evaluate early bone marrow microvascular changes in alloxan-induced diabetic rabbits using IDEAL-IQ fat quantification, texture analysis based on DCE-MRI K^trans map, and metabolomics.

Materials and methods

24 male Japanese rabbits were randomly divided into diabetic (n = 12) and control (n = 12) groups. All rabbits underwent sagittal MRI of the lumbar vertebrae at the 0th,4th, 8th, 12th, and 16th week, respectively. The fat fraction (FF) ratio and quantitative permeability of the lumbar bone marrow was measured. Texture parameters were extracted from DCE-MRI K^trans map. At 16th week, lumbar vertebrae 5 and 6 were used for histological analysis. Lumbar vertebra 7 was crushed to obtain bone marrow for metabolomics research.

Results

The

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11406872 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature