Gut dysbiosis contributes to the development of Budd-Chiari syndrome through immune imbalance.

ABSTRACT: Budd-Chiari syndrome (B-CS) is a rare and lethal condition characterized by hepatic venous outflow tract blockage. Gut microbiota has been linked to numerous hepatic disorders, but its significance in B-CS pathogenesis is uncertain. First, we performed a case-control study (N_case = 140, N_control = 63) to compare the fecal microbiota of B-CS and healthy individuals by metagenomics sequencing. B-CS patients' gut microbial composition and activity changed significantly, with a different metagenomic makeup, increased potentially pathogenic bacteria, including Prevotella, and disease-linked microbial function. Imbalanced cytokines in patients were demonstrated to be associated with gut dysbiosis, which led us to suspect that B-CS is associated with gut

SUBMITTER: Lu Q 

PROVIDER: S-EPMC11406926 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature