A genome-scale metabolic model of a globally disseminated hyperinvasive M1 strain of <i>Streptococcus pyogenes</i>.

ABSTRACT: Streptococcus pyogenes is responsible for a range of diseases in humans contributing significantly to morbidity and mortality. Among more than 200 serotypes of S. pyogenes, serotype M1 strains hold the greatest clinical relevance due to their high prevalence in severe human infections. To enhance our understanding of pathogenesis and discovery of potential therapeutic approaches, we have developed the first genome-scale metabolic model (GEM) for a serotype M1 S. pyogenes strain, which we name iYH543. The curation of iYH543 involved cross-referencing a draft GEM of S. pyogenes serotype M1 from the AGORA2 database with gene essentiality and autotrophy data obtained from transposon mutagenesis-based and growth screens. We achieved a 92.6% (503/543 genes) accuracy i

SUBMITTER: Hirose Y 

PROVIDER: S-EPMC11406949 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature