Protective role of cytosolic prion protein against virus infection in prion-infected cells.

ABSTRACT: Production of the amyloidogenic prion protein, PrP^Sc, which forms infectious protein aggregates, or prions, is a key pathogenic event in prion diseases. Functional prion-like protein aggregations, such as the mitochondrial adaptor protein MAVS and the inflammasome component protein ASC, have been identified to play a protective role in viral infections in mammalian cells. In this study, to investigate if PrP^Sc could play a functional role against external stimuli, we infected prion-infected cells with a neurotropic influenza A virus strain, IAV/WSN. We found that prion-infected cells were highly resistant to IAV/WSN infection. In these cells, NF-κB nuclear translocation was disturbed; therefore, mitochondrial superoxide dismutase (mtSOD) expression was suppressed, and

SUBMITTER: Hara H 

PROVIDER: S-EPMC11406989 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature