A study on the methylation patterns of DIO3 in patients with heart failure and its correlation with key clinical parameters.

ABSTRACT:

Objective

This study aimed to analyze the methylation pattern of deoxyribonucleic acid (CpG) sites in the DIO3_FA26 promoter region of patients with heart failure (HF) and explore the correlation between differential CpG methylation levels and various clinical parameters.

Methods

Peripheral blood specimens were collected from 20 patients with HF and 20 healthy individuals. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was used to identify and detect the CpG sites in the DIO3_FA26 promoter region. CpG methylation levels were compared between patients with HF and healthy controls and patients with HF with different levels of cardiac function.

Results

The methylation level of DIO3_FA26_CpG_17.18 in patients with HF was

SUBMITTER: Miao Q 

PROVIDER: S-EPMC11407046 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature