Intermittent ozone inhalation during house dust mite-induced sensitization primes for adverse asthma phenotype.

ABSTRACT: The ability of air pollution to induce acute exacerbation of asthma is well documented. However, the ability of ozone (O₃), the most reactive gaseous component of air pollution, to function as a modulator during sensitization is not well established. C57BL/6 J male mice were intranasally sensitized to house dust mite (HDM) (40 μg/kg) for 3 weeks on alternate days in parallel with once-a-week O₃ exposure (1 ppm). Mice were euthanized 24 h following the last HDM challenge. Lung lavage, histology, lung function (both forced oscillation and forced expiration-based), immune cell profiling, inflammation (pulmonary and systemic), and immunoglobulin production were assessed. Compared to HDM alone, HDM + O₃ leads to a significant increase in peribronchial inflammati

SUBMITTER: Hussain S 

PROVIDER: S-EPMC11407077 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature