Association of hemoglobin with plasma neurofilament light and white matter hyperintensities in Alzheimer's disease continuum.

ABSTRACT:

Objective

This study aimed to investigate the association of hemoglobin (Hb) with axonal injury marker plasma neurofilament light (PNFL) and brain structure measurements in the Alzheimer's disease (AD) continuum.

Methods

The data used in this study were collected from the Alzheimer's Disease Neuroimaging Initiative database. Participants with cognitively normal, mild cognitive impairment, and mild dementia were included in the data analyses. All participants had available data on blood tests, PNFL levels, neuropsychological assessments, brain structure measurements (including volumes of white matter hyperintensities [WMH], hippocampus, gray matter, and total brain), and Aβ positron emission tomography standardized uptake value ratio (SUVR) at baseline. Aβ-positive was define

SUBMITTER: Li Q 

PROVIDER: S-EPMC11407093 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature