Effect of the immune cells and plasma metabolites on rheumatoid arthritis: a mediated mendelian randomization study.

ABSTRACT:

Background

Increasing evidence indicates a close relationship between alterations in human immune cells and plasma metabolites with Rheumatoid Arthritis (RA). However, limited studies have left the causal relationships behind these links unclear.

Methods

A bidirectional Mendelian Randomization (MR) study was conducted, combined with mediation analysis, using data from genome-wide association study database covering 731 immune cell phenotypes and 1,400 plasma metabolite traits to explore their causal relationships with RA and potential mediating effects. The primary method used for MR analysis was inverse-variance weighted and False Discovery Rate (FDR) correction was applied to verify the robustness of our results.

Results

HLA DR on CD33- HLA DR+ (myeloid cell group)

SUBMITTER: Liu QP 

PROVIDER: S-EPMC11407113 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature