Exploring the impact of diabetes on aging: insights from TERT and COL1A1 methylation.

ABSTRACT:

Background/aim

Aging, a multifaceted biological process, leads to diminished physical performance, especially in older adults with diabetes, where a mismatch between biological and chronological age is noticeable. Numerous studies have demonstrated that diabetes accelerates aging at the cellular and organ levels. Notable aging markers are telomerase reverse transcriptase (TERT), related to telomere length, and type 1 chain collagen (COL1A1), a key component of skin collagen. Additionally, age-related methylation increases, as revealed through methylation analysis, augmenting aspects of aging. However, the detailed interplay between aging and diabetes, particularly regarding methylation, remains underexplored and warrants further study to elucidate the biological links between the t

SUBMITTER: Liamri JN 

PROVIDER: S-EPMC11407328 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature