Serum metabolomics profile identifies patients with community-acquired pneumonia infected by bacteria, fungi, and viruses.

ABSTRACT:

Purpose

Patients with bacterial, fungal, and viral community-acquired pneumonia (CAP) were studied to determine their metabolic profiles.

Methods

Loop-mediated isothermal amplification technology and nucleic acid sequence-dependent amplification combined with microfluidic chip technology were applied to screen multiple pathogens from respiratory tract samples. Eighteen patients with single bacterial infection (B-CAP), fifteen with single virus infection (V-CAP), twenty with single fungal infection (F-CAP), and twenty controls were enrolled. UHPLC-MS/MS analysis of untargeted serum samples for metabolic profiles. Multiple linear regression and Spearman's rank correlation analysis were used to determine associations between metabolites and clinical parameters. The sensitivity

SUBMITTER: Chen L 

PROVIDER: S-EPMC11407381 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature