Adaptations to cationic biocide exposure differentially influence virulence factors and pathogenicity in <i>Pseudomonas aeruginosa</i>.

ABSTRACT: Cationic biocides (CBs), which include quaternary ammonium compounds (QACs), are employed to mitigate the spread of infectious bacteria, but resistance to such surface disinfectants is rising. CB exposure can have profound phenotypic implications that extend beyond allowing microorganisms to persist on surfaces. Pseudomonas aeruginosa is a deadly bacterial pathogen that is intrinsically tolerant to a wide variety of antimicrobials and is commonly spread in healthcare settings. In this study, we pursued resistance selection assays to the QAC benzalkonium chloride and quaternary phosphonium compound P6P-10,10 to assess the phenotypic effects of CB exposure in P. aeruginosa PAO1 and four genetically diverse, drug-resistant clinical isolates. In particular, we sought to examine h

SUBMITTER: Vargas-Cuebas GG 

PROVIDER: S-EPMC11407422 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature