Evaluation of the effect of reducing administered activity on assessment of function in cardiac gated SPECT.

ABSTRACT:

Background

We previously optimized several reconstruction strategies in SPECT myocardial perfusion imaging (MPI) with low dose for perfusion-defect detection. Here we investigate whether reducing the administered activity can also maintain the diagnostic accuracy in evaluating cardiac function.

Methods

We quantified the myocardial motion in cardiac-gated stress 99m-Tc-sestamibi SPECT studies from 163 subjects acquired with full dose (29.8 ± 3.6 mCi), and evaluated the agreement of the obtained motion/thickening and ejection fraction (EF) measures at various reduced dose levels (uniform reduction or personalized dose) with that at full dose. We also quantified the detectability of abnormal motion via a receiver-operating characteristics (ROC) study. For reconstruction we cons

SUBMITTER: Juan Ramon A 

PROVIDER: S-EPMC11407505 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature