APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage.

ABSTRACT: Aim: The aim of this study was to assess the utility of weighted amide proton transfer (APT_w) MRI in three different rodent models of hepatocellular carcinoma (HCC).Methods: APT_w MRI was evaluated in models of diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft and human HepG2 ectopic xenograft.Results: All models of HCC showed a higher APT_w signal over the surrounding normal tissues. In the DEN model, the APT_w signal could differentiate HCC lesions from benign nodules. Intra-arterial administration of low-density lipoprotein docosahexaenoic acid (LDL-DHA) nanoparticles to N1S1 xenografts rapidly lowered the tumor APT_w signal within 72 h. Direct injections of LDL-DHA nanoparticles into HepG2 x

SUBMITTER: Wang X 

PROVIDER: S-EPMC11407511 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature