Orientational Chirality, Its Asymmetric Control, and Computational Study.

ABSTRACT: Orientational chirality was discovered and characterized by a C(sp)-C(sp³) axis-anchored chiral center and a remotely anchored blocker. X-ray structural analysis proved that orientatiomers are stabilized by through-space functional groups, making it possible for 1 R- or S-chiral center to exhibit 3 orientational isomers simply by rotating operations. A new model system was proposed, fundamentally different from the traditional Felkin-Ahn-type or Cram-type models. In these traditional models, chiral C(sp³) center and blocking C(sp²) carbons are connected adjacently, and there exist 6 energy barriers during rotating along the C(sp²)-C(sp³) axis. In comparison, the present orientational chirality model shows that a chiral C(

SUBMITTER: Jin S 

PROVIDER: S-EPMC11407581 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature