Regulatory Mechanisms for Transcriptional Bursting Revealed by an Event-Based Model.

ABSTRACT: Gene transcription often occurs in discrete bursts, and it can be difficult to deduce the underlying regulatory mechanisms for transcriptional bursting with limited experimental data. Here, we categorize numerous states of single eukaryotic genes and identify 6 essential transcriptional events, each comprising a series of state transitions; transcriptional bursting is characterized as a sequence of 4 events, capable of being organized in various configurations, in addition to the beginning and ending events. By associating transcriptional kinetics with mean durations and recurrence probabilities of the events, we unravel how transcriptional bursting is modulated by various regulators including transcription factors. Through analytical derivation and numerical simulation, this study reveals

SUBMITTER: Wu R 

PROVIDER: S-EPMC11407585 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature