Repurposing auranofin and meclofenamic acid as energy-metabolism inhibitors and anti-cancer drugs.

ABSTRACT:

Objective

Cytotoxicity of the antirheumatic drug auranofin (Aur) and the non-steroidal anti-inflammatory drug meclofenamic acid (MA) on several cancer cell lines and isolated mitochondria was examined to assess whether these drugs behave as oxidative phosphorylation inhibitors.

Methods

The effect of Aur or MA for 24 h was assayed on metastatic cancer and non-cancer cell proliferation, energy metabolism, mitophagy and metastasis; as well as on oxygen consumption rates of cancer and non-cancer mitochondria.

Results

Aur doses in the low micromolar range were required to decrease proliferation of metastatic HeLa and MDA-MB-231 cells, whereas one or two orders of magnitude higher levels were required to affect proliferation of non-cancer cells. MA doses required to affect

SUBMITTER: Rodriguez-Enriquez S 

PROVIDER: S-EPMC11407620 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature