Identification of antibody targets associated with lower HIV viral load and viremic control.

ABSTRACT:

Background

High HIV viral loads (VL) are associated with increased morbidity, mortality, and on-going transmission. HIV controllers maintain low VLs in the absence of antiretroviral therapy (ART). We previously used a massively multiplexed antibody profiling assay (VirScan) to compare antibody profiles in HIV controllers and persons living with HIV (PWH) who were virally suppressed on ART. In this report, we used VirScan to evaluate whether antibody reactivity to specific HIV targets and broad reactivity across the HIV genome was associated with VL and controller status 1-2 years after infection.

Methods

Samples were obtained from participants who acquired HIV infection in a community-randomized trial in Africa that evaluated an integrated strategy for HIV prevention (HPTN 0

SUBMITTER: Grant-McAuley W 

PROVIDER: S-EPMC11407625 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature