Microtubules, Membranes, and Movement: New Roles for Stathmin-2 in Axon Integrity.

ABSTRACT: Neurons establish functional connections responsible for how we perceive and react to the world around us. Communication from a neuron to its target cell occurs through a long projection called an axon. Axon distances can exceed 1 m in length in humans and require a dynamic microtubule cytoskeleton for growth during development and maintenance in adulthood. Stathmins are microtubule-associated proteins that function as relays between kinase signaling and microtubule polymerization. In this review, we describe the prolific role of Stathmins in microtubule homeostasis with an emphasis on emerging roles for Stathmin-2 (Stmn2) in axon integrity and neurodegeneration. Stmn2 levels are altered in Amyotrophic Lateral Sclerosis and loss of Stmn2 provokes motor and sensory neuropathies. There is gr

SUBMITTER: Thornburg-Suresh EJC 

PROVIDER: S-EPMC11407747 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature