Cell-type-specific origins of locomotor rhythmicity at different speeds in larval zebrafish.

ABSTRACT: Different speeds of locomotion require heterogeneous spinal populations, but a common mode of rhythm generation is presumed to exist. Here, we explore the cellular versus synaptic origins of spinal rhythmicity at different speeds by performing electrophysiological recordings from premotor excitatory interneurons in larval zebrafish. Chx10-labeled V2a neurons are divided into at least two morphological subtypes proposed to play distinct roles in timing and intensity control. Consistent with distinct rhythm generating and output patterning functions within the spinal V2a population, we find that descending subtypes are recruited exclusively at slow or fast speeds and exhibit intrinsic cellular properties suitable for rhythmogenesis at those speeds, while bifurcating subtypes are recruited mo

SUBMITTER: Agha MA 

PROVIDER: S-EPMC11407768 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature