A micro-scale humanized ventilator-on-a-chip to examine the injurious effects of mechanical ventilation.

ABSTRACT: Patients with compromised respiratory function frequently require mechanical ventilation to survive. Unfortunately, non-uniform ventilation of injured lungs generates complex mechanical forces that lead to ventilator induced lung injury (VILI). Although investigators have developed lung-on-a-chip systems to simulate normal respiration, modeling the complex mechanics of VILI as well as the subsequent recovery phase is a challenge. Here we present a novel humanized in vitro ventilator-on-a-chip (VOC) model of the lung microenvironment that simulates the different types of injurious forces generated in the lung during mechanical ventilation. We used transepithelial/endothelial electrical impedance measurements to investigate how individual and simultaneous application of mechanical for

SUBMITTER: Gabela-Zuniga B 

PROVIDER: S-EPMC11407794 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature