Placental Extracellular Vesicles Can Be Loaded with Plasmid DNA.

ABSTRACT: Recently, extracellular vesicles (EVs) have garnered considerable interest as potential vehicles for drug delivery, including gene therapy. Although EVs from diverse sources have been investigated, current techniques used in the field for EV generation limit large-scale EV production. The placenta is essentially a tissue transplant and has unique properties that allow it to avoid the maternal immune system making it likely that placental EVs will not generate inflammatory responses and will avoid clearance by the immune system. We propose that placental EVs produced from explant cultures are an efficient method to produce considerable quantities of EVs that would be safe to administer, and we hypothesize that placental EVs can be loaded with large exogenous plasmids. To this end, we triale

SUBMITTER: Kang M 

PROVIDER: S-EPMC11407900 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature