Increased DNA damage of adipose tissue-derived mesenchymal stem cells under inflammatory conditions.

ABSTRACT: Cells have evolved various DNA repair mechanisms to prevent DNA damage from building up. Malfunctions during DNA repair can influence cellular homeostasis because they can bring on genomic instability through the improper recognition of DNA damage or dysregulation of the repair process. Maintaining proper DNA repair is also essential for stem cells (SCs), as they provide a differentiated cell population to the living organism. SCs are regularly used in personalized stem cell therapy. Patients must be treated with specific activators to produce these SCs effectively. This report investigated the impact of treating mesenchymal stem cells (MSC) with lipopolysaccharide, tumor necrosis factor, interferon-gamma, polyinosinic acid, interleukin 1 beta, while monitoring their transcription-related

SUBMITTER: Pahi ZG 

PROVIDER: S-EPMC11407982 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature