Causal effect of COVID-19 on longitudinal volumetric changes in subcortical structures: A mendelian randomization study.

ABSTRACT: A few observational neuroimaging investigations have reported subcortical structural changes in the individuals who recovered from the coronavirus disease-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the causal relationships between COVID-19 and longitudinal changes of subcortical structures remain unclear. We performed two-sample Mendelian randomization (MR) analyses to estimate putative causal relationships between three COVID-19 phenotypes (susceptibility, hospitalization, and severity) and longitudinal volumetric changes of seven subcortical structures derived from MRI. Our findings demonstrated that genetic liability to SARS-CoV-2 infection had a great long-term impact on the volumetric reduction of subcortical structures, especially caud

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11408012 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature