Association between substituting macronutrients and all-cause mortality: a network meta-analysis of prospective observational studies.

ABSTRACT:

Background

Suboptimal diet quality is a key risk factor for premature death. Assuming relatively stable energy intake among individuals, changes in nutrient intakes occur by exchanging different nutrients. Therefore we aimed to examine the association of isocaloric substitution of dietary (macro)nutrients with all-cause mortality using network meta-analysis (NMA).

Methods

For this systematic review and NMA of prospective observational studies MEDLINE, Embase, and Scopus were searched from inception to February 13th, 2024. Eligible studies reported substitution analyses for quantity and/or quality of macronutrients, including carbohydrates, proteins, and fatty acids on all-cause mortality. Random-effects NMA were used in order to evaluate the pooled hazard ratios (HR) and 95%

SUBMITTER: Wallerer S 

PROVIDER: S-EPMC11408053 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature