CD133⁺/ABCC5⁺ cervical cancer cells exhibit cancer stem cell properties.

ABSTRACT:

Objective

This study explores the correlation between Forkhead box M1 (FOXM1) and ATP-binding cassette subfamily C member 5 (ABCC5) in relation to paclitaxel resistance in cervical cancer. It aims to identify potential cervical cancer stem cell markers, offering fresh perspectives for developing therapeutic strategies to overcome paclitaxel chemoresistance in cervical cancer.

Methods

Paclitaxel-resistant Hela cells (Hela/Taxol) were developed by intermittently exposing Hela cells to progressively increasing concentrations of paclitaxel. We assessed the biological properties of both Hela and Hela/Taxol cells using various assays: cell proliferation, clonogenic, cell cycle, apoptosis, scratch, and transwell. To determine which markers better represent tumor stem cells, we anal

SUBMITTER: He L 

PROVIDER: S-EPMC11408061 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature