Dexmedetomidine directly binds to and inhibits Toll-like receptor 4.

ABSTRACT:

Background

While a number of anesthetics has been shown potentially associated with neurotoxicity in the developing brain, dexmedetomidine, a drug that was rather recently introduced into the perioperative setting, is considered beneficial from neurological wellbeing. However, the underlying mechanism of how dexmedetomidine affects brain health remains to be determined. Based on our recent study, we hypothesized that dexmedetomidine would directly bind to and inhibit Toll-like receptor 4 (TLR4), a critical receptor largely expressed in microglia and responsible for neurological insult.

Methods

We used TLR4 reporter assays to test if dexmedetomidine attenuates TLR4 activation. Furthermore, a direct binding of dexmedetomidine on TLR4 was tested using photoactivatable medetomid

SUBMITTER: Koutsogiannaki S 

PROVIDER: S-EPMC11408083 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature