Pathophysiologic Vasodilation in Cardiogenic Shock and Its Impact on Mortality.

ABSTRACT:

Background

Cardiogenic shock (CS) mortality remains near 40%. In addition to inadequate cardiac output, patients with severe CS may exhibit vasodilation. We aimed to examine the prevalence and consequences of vasodilation in CS.

Methods

We analyzed all patients hospitalized at a CS referral center who were diagnosed with CS stages B to E and did not have concurrent sepsis or recent cardiac surgery. Vasodilation was defined by lower systemic vascular resistance (SVR), higher norepinephrine equivalent dose, or a blunted SVR response to pressors. Threshold SVR values were determined by their relation to 14-day mortality in spline models. The primary outcome was death within 14 days of CS onset in multivariable-adjusted Cox models.

Results

This study included 713 patients

SUBMITTER: Chavez MA 

PROVIDER: S-EPMC11408100 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature