Genetic association and causal effects between inflammatory bowel disease and conjunctivitis.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) is often clinically associated with conjunctivitis, which may result from genetic associations and causal effects.

Methods

Genetic correlations were investigated through the genome-wide association study (GWAS) data on IBD and conjunctivitis using the linkage disequilibrium score regression (LDSC) and heritability estimated in summary statistics (HESS). The causal effect analysis was performed using four methods of Mendelian randomization (MR) and the genetic risk loci common to both diseases were identified by the statistical method of conditional/conjoint false discovery rate (cond/conjFDR), followed by genetic overlap analysis. Finally, a multi-trait GWAS analysis (MTAG) was performed to validate the identified shared loci.

R

SUBMITTER: Chang S 

PROVIDER: S-EPMC11408187 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature