Enabling 3D bioprinting of cell-laden pure collagen scaffolds via tannic acid supporting bath.

ABSTRACT: The fabrication of cell-laden biomimetic scaffolds represents a pillar of tissue engineering and regenerative medicine (TERM) strategies, and collagen is the gold standard matrix for cells to be. In the recent years, extrusion 3D bioprinting introduced new possibilities to increase collagen scaffold performances thanks to the precision, reproducibility, and spatial control. However, the design of pure collagen bioinks represents a challenge, due to the low storage modulus and the long gelation time, which strongly impede the extrusion of a collagen filament and the retention of the desired shape post-printing. In this study, the tannic acid-mediated crosslinking of the outer layer of collagen is proposed as strategy to enable collagen filament extrusion. For this purpose, a tannic acid sol

SUBMITTER: Palladino S 

PROVIDER: S-EPMC11408190 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature