Insights from pharmacovigilance and pharmacodynamics on cardiovascular safety signals of NSAIDs.

ABSTRACT:

Background and aim

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat fever, pain, and inflammation. Concerns regarding their cardiovascular safety have been raised. However, the underlying mechanism behind these events remains unknown. We aim to investigate the cardiovascular safety signals and receptor mechanisms of NSAIDs, employing a comprehensive approach that integrates pharmacovigilance and pharmacodynamics.

Methods

This study utilized a pharmacovigilance-pharmacodynamic approach to evaluate the cardiovascular safety of NSAIDs and explore potential receptor mechanisms involved. Data were analyzed using the OpenVigil 2.1 web application, which grants access to the FDA Adverse Event Reporting System (FAERS) database, in conjunction with the Bindin

SUBMITTER: Liang S 

PROVIDER: S-EPMC11408209 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature