Role of factor H-related protein 3 in Pseudomonas aeruginosa bloodstream infections.

ABSTRACT: Pseudomonas aeruginosa is a leading cause of nosocomial bloodstream infections. The outcome of these infections depends on the virulence of the microorganism as well as host-related conditions and factors. The complement system plays a crucial role in defense against bloodstream infections. P. aeruginosa counteracts complement attack by recruiting Factor H (FH) that inhibits complement amplification on the bacterial surface. Factor H-related proteins (FHRs) are a group of plasma proteins evolutionarily related to FH that have been postulated to interfere this bacterial evasion mechanism. In this study, we demonstrate that FHR-3 competes with purified FH for binding to P. aeruginosa and identify EF-Tu as a common bacterial target for both complement regulator factors. Importan

SUBMITTER: Gonzalez-Alsina A 

PROVIDER: S-EPMC11408224 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature