Divergent suicidal symptomatic activations converge on somato-cognitive action network in depression.

ABSTRACT: Individuals with depression have the highest lifetime prevalence of suicide attempts (SA) among mental illnesses. Numerous neuroimaging studies have developed biomarkers from task-related neural activation in depressive patients with SA, but the findings are inconsistent. Empowered by the contemporary interconnected view of depression as a neural system disorder, we sought to identify a specific brain circuit utilizing published heterogeneous neural activations. We systematically reviewed all published cognitive and emotional task-related functional MRI studies that investigated differences in the location of neural activations between depressive patients with and without SA. We subsequently mapped an underlying brain circuit functionally connecting to each experimental activation using a

SUBMITTER: Li J 

PROVIDER: S-EPMC11408245 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature