Proteomics identifies potential immunological drivers of postinfection brain atrophy and cognitive decline.

ABSTRACT: Infections have been associated with the incidence of Alzheimer disease and related dementias, but the mechanisms responsible for these associations remain unclear. Using a multicohort approach, we found that influenza, viral, respiratory, and skin and subcutaneous infections were associated with increased long-term dementia risk. These infections were also associated with region-specific brain volume loss, most commonly in the temporal lobe. We identified 260 out of 942 immunologically relevant proteins in plasma that were differentially expressed in individuals with an infection history. Of the infection-related proteins, 35 predicted volumetric changes in brain regions vulnerable to infection-specific atrophy. Several of these proteins, including PIK3CG, PACSIN2, and PRKCB, were related

SUBMITTER: Duggan MR 

PROVIDER: S-EPMC11408246 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature