Plasma metabolites associated with biopsychosocial parameters in overweight/obese women with severe knee osteoarthritis.

ABSTRACT:

Introduction

Obesity aligned with quadriceps muscle weakness contributes to the high incidence of knee osteoarthritis (KOA), which is prevalent in women. Although molecular signatures of KOA have been suggested, the association between biopsychosocial responses and the plasma metabolomic profile in overweight/ obese women with KOA remains in its early stages of investigation. This study aims to associate the plasma metabolome with biopsychosocial parameters of overweight/obese women diagnosed with KOA.

Methods

Twenty-eight overweight/obese women (Control-n = 14; KOA-n = 14) underwent two visits to the laboratory. Functional tests and questionnaires assessing biopsychosocial parameters were administered during the first visit. After 48 h, the participants returned to the labo

SUBMITTER: Lisboa FSS 

PROVIDER: S-EPMC11408288 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature