Electroencephalographic Microstates During Sleep and Wake in Schizophrenia.

ABSTRACT:

Background

Aberrant functional connectivity is a hallmark of schizophrenia. The precise nature and mechanism of dysconnectivity in schizophrenia remains unclear, but evidence suggests that dysconnectivity is different in wake versus sleep. Microstate analysis uses electroencephalography (EEG) to investigate large-scale patterns of coordinated brain activity by clustering EEG data into a small set of recurring spatial patterns, or microstates. We hypothesized that this technique would allow us to probe connectivity between brain networks at a fine temporal resolution and uncover previously unknown sleep-specific dysconnectivity.

Methods

We studied microstates during sleep in patients with schizophrenia by analyzing high-density EEG sleep data from 114 patients with schizophre

SUBMITTER: Murphy M 

PROVIDER: S-EPMC11408315 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature