Evaluation of circulating plasma proteins in prostate cancer using mendelian randomization.

ABSTRACT:

Background

The proteome is an important resource for exploring potential diagnostic and therapeutic targets for cancer. This study aimed to investigate the causal associations between plasma proteins and prostate cancer (PCa), and to explore the downstream phenotypes that plasma proteins may influence and potential upstream intervening factors.

Methods

Proteome-wide Mendelian randomization was used to investigate the causal effects of plasma proteins on PCa. Colocalization analysis examined the common causal variants between plasma proteins and PCa. Summary-statistics-based Mendelian Randomization (SMR) analyses identified associations between the expression of protein-coding genes and PCa. Phenome-wide association study was performed to explore the effect of target proteins

SUBMITTER: Cheng L 

PROVIDER: S-EPMC11408438 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature