Atomic vacancies of molybdenum disulfide nanoparticles stimulate mitochondrial biogenesis.

ABSTRACT: Diminished mitochondrial function underlies many rare inborn errors of energy metabolism and contributes to more common age-associated metabolic and neurodegenerative disorders. Thus, boosting mitochondrial biogenesis has been proposed as a potential therapeutic approach for these diseases; however, currently we have a limited arsenal of compounds that can stimulate mitochondrial function. In this study, we designed molybdenum disulfide (MoS₂) nanoflowers with predefined atomic vacancies that are fabricated by self-assembly of individual two-dimensional MoS₂ nanosheets. Treatment of mammalian cells with MoS₂ nanoflowers increased mitochondrial biogenesis by induction of PGC-1α and TFAM, which resulted in increased mitochondrial DNA copy number, enhanced exp

SUBMITTER: Singh KA 

PROVIDER: S-EPMC11408498 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature