Effective bolus dose of remimazolam for i-gel^® insertion in nonparalyzed patients: a dose-finding study.

ABSTRACT:

Purpose

Remimazolam is a recently developed ultra-short-acting benzodiazepine used for anesthesia induction and maintenance. Nevertheless, the effective bolus dose of remimazolam for i-gel^® (Intersurgical Ltd., Wokingham, Berkshire, UK) insertion without the use of neuromuscular blocking agents (NMBAs) has not been well established.

Methods

This study included 25 adult patients scheduled for surgery under general anesthesia who were eligible for i-gel use. Anesthesia was induced with predetermined bolus doses of remimazolam, starting at 0.3 mg·kg^-1 for the first patient, without the use of NMBAs. All patients concurrently received remifentanil using target-controlled infusion (TCI) at a fixed effect-site concentration (Ce) of 3.0 ng·mL^-1. Ins

SUBMITTER: Cho E 

PROVIDER: S-EPMC11408568 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature