DNA Methylation signatures underpinning blood neutrophil to lymphocyte ratio during first week of human life.

ABSTRACT: Understanding of newborn immune ontogeny in the first week of life will enable age-appropriate strategies for safeguarding vulnerable newborns against infectious diseases. Here we conducted an observational study exploring the immunological profile of infants longitudinally throughout their first week of life. Our Expanded Program on Immunization - Human Immunology Project Consortium (EPIC-HIPC) studies the epigenetic regulation of systemic immunity using small volumes of peripheral blood samples collected from West African neonates on days of life (DOL) 0, 1, 3, and 7. Genome-wide DNA methylation and single nucleotide polymorphism markers are examined alongside matched transcriptomic and flow cytometric data. Integrative analysis reveals that a core network of transcription factors mediat

SUBMITTER: Martino D 

PROVIDER: S-EPMC11408723 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature