Association of rs2241766 and rs1501299 polymorphisms in the adiponectin gene with metabolic syndrome.

ABSTRACT:

Objective

To investigate the influence of adiponectin (APN) rs2241766 and rs1501299 polymorphisms on adiponectin levels and their association with metabolic syndrome (MetS).

Methods

Analyzed two polymorphisms (rs2241766 and rs1501299) of the adiponectin gene (ADIPOQ) in 210 MetS patients and 102 control patients using the polymerase chain reaction-restriction fragment length polymorphism method and DNA sequencing technology.

Results

The genotypes of the rs2241766 T/G and rs1501299 G/T polymorphism were significantly associated with serum APN levels in MetS patients. The ADIPOQ polymorphisms were associated with a risk of MetS when compared with that in healthy controls. TG and GG genotypes of rs2241766 were associated with a significantly elevated risk of MetS as comp

SUBMITTER: Tang Y 

PROVIDER: S-EPMC11408748 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature