Asthma diagnosis: a comparison of established diagnostic guidelines in adults with respiratory symptoms.

ABSTRACT:

Background

Considerable variability exists between asthma diagnostic guidelines. We tested the performance characteristics of the European Respiratory Society (ERS), the National Institute for Health and Care Excellence (NICE) and the Global Initiative for Asthma (GINA) guidelines for the diagnosis of asthma in adults.

Methods

In this prospective observational study (ISRCTN-11676160, May 2019-June 2022), participants referred from primary care with clinician-suspected asthma underwent comprehensive investigation including: spirometry, bronchodilator reversibility, fractional exhaled nitric oxide, peak expiratory flow variability, bronchial challenge testing with methacholine and mannitol, and responsiveness to inhaled corticosteroid therapy. Results were reviewed by a panel

SUBMITTER: Simpson AJ 

PROVIDER: S-EPMC11408836 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature