Differential utilization of vitamin B₁₂-dependent and independent pathways for propionate metabolism across human cells.

ABSTRACT: Propionic acid links the oxidation of branched-chain amino acids and odd-chain fatty acids to the TCA cycle. Gut microbes ferment complex fiber remnants, generating high concentrations of short chain fatty acids, acetate, propionate and butyrate, which are shared with the host as fuel sources. Analysis of vitamin B₁₂-dependent propionate utilization in skin biopsy samples has been used to characterize and diagnose underlying inborn errors of cobalamin (or B₁₂) metabolism. In these cells, the B₁₂-dependent enzyme, methylmalonyl-CoA mutase (MMUT), plays a central role in funneling propionate to the TCA cycle intermediate, succinate. Our understanding of the fate of propionate in other cell types, specifically, the involvement of the β-oxidation-like and methy

SUBMITTER: Gouda H 

PROVIDER: S-EPMC11408853 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature