A pan-cancer analysis of the association of METRN with prognosis and immune infiltration in human tumors.

ABSTRACT:

Background

Meteorin (METRN) is expressed predominantly in the central nervous system (CNS), where it functions by regulating glial cell differentiation and promoting axonal elongation. Nonetheless, its function within tumors is still not well understood. In this study, we focused on investigating its expression across various cancers and delving deeper into how METRN expression correlates with prognosis and immune infiltration.

Methods

We explored METRN expression patterns in pan-cancers utilizing data obtained from the UCSC Xena and TCGA. In addition, analyses of survival and clinical association were conducted for tumors where METRN could affect the prognosis. Subsequently, nomogram models were constructed for sarcoma (SARC) and prostate adenocarcinoma (PRAD) to verify MET

SUBMITTER: Wang L 

PROVIDER: S-EPMC11408854 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature