Transcriptome Analysis of Choroidal Endothelium Links Androgen Receptor Role to Central Serous Chorioretinopathy.

ABSTRACT:

Background

Central Serous Chorioretinopathy (CSCR) manifests as fluid accumulation between the neurosensory retina and the retinal pigment epithelium (RPE). Elevated levels of steroid hormones have been implicated in CSCR pathogenesis. This investigation aims to delineate the gene expression patterns of CSCR-associated risk and steroid receptors across human choroidal cell types and RPE cells to discern potential underlying mechanisms.

Methods

This study utilized a comprehensive query of transcriptomic data derived from non-pathological human choroid and RPE cells.

Findings

CSCR-associated genes such as PTPRB, CFH, and others are predominantly expressed in the choroidal endothelium as opposed to the RPE. The androgen receptor, encoded by the AR ge

SUBMITTER: Kunzel SH 

PROVIDER: S-EPMC11408951 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature